Abstract #1003

Combined 18F-FDG PET/DTI reveals concurrent more extensive brain damage in mesial temporal lobe epilepsy

Chuan Huang^1,2, Tianyun Zhao², Siyu Yuan³, Hui Huang³, Miao Zhang⁴, and Jie Luo³

¹Radiology, Stony Brook Medicine, Stony Brook, NY, United States, ²Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ³School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁴Department of Nuclear Medicine, Ruijin Hospital, Shanghai, China

Synopsis

Keywords: Epilepsy, EpilepsyMesial temporal lobe epilepsy is the most common type of drug-resistant epilepsy, with hippocampus sclerosis (HS) being its most common pathology. Anterior temporal lobectomy is the most common surgical strategy for these patients, many still suffer from seizures post-surgery, which may relate to their extensive brain network damage. 18F-FDG-PET is sensitive to metabolic changes in the epileptogenic zone. DTI can assess the integrity of white-matter tracts. In this study, we investigated the changes in glucose uptake, white-matter tracts, and their differences in brain networks of MR-HS versus MR-negative patients using simultaneous PET/MR, and studied if these changes coincide topographically.

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