Abstract #1004

Can fMRI metrics lateralize epileptogenic hypometabolic FDG-PET regions? A simultaneous PET/MR investigation in focal epilepsy

Daniel Uher^1,2,3, Gerhard S. Drenthen^1,2, Tineke van de Weijer², Jochem van der Pol², Rob Rouhl², Olaf E.M.G. Schijns^1,3,4, Albert J. Colon⁴, Walter H. Backes^1,2, and Jacobus F.A. Jansen^1,2,4,5

¹School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands, ²Department of Radiology & Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, ³Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, Netherlands, ⁴Academic Centre for Epileptology, Kempenhaeghe/Maastricht University Medical Centre, Maastricht, Netherlands, ⁵Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Synopsis

Keywords: Epilepsy, PET/MRLocally reduced glucose metabolism (i.e. hypometabolism) derived from the 18-FDG positron emission tomography (FDG-PET) is considered to be a valuable biomarker for epileptogenic zone localization. Spontaneous fluctuations in blood-oxygen-level-dependent fMRI (BOLD fMRI) can indirectly measure neuronal activity. Studies have suggested that the fMRI-derived metrics may be indicative of the epileptogenic zone localization, however the potential for fMRI to reflect and lateralize the hypometabolic FDG-PET regions remains underdetermined. Here, both static and dynamic fMRI-derived metrics were calculated and we assessed their potential for lateralizing the hypometabolic FDG-PET regions in patients with unilateral focal epilepsy.

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