Keywords: Epilepsy, fMRI (task based), Memory function; Pre-surgical assessment; Clinical implementation; Clinical reliabilityMemory-activated functional MRI (fMRI) is increasingly implemented in the clinic to assess memory function and inform pre-surgical decision making in refractory epilepsy. The Home Town Walking (HTW) fMRI paradigm has been shown to activate the parahippocampal gyri (PHG) and help determine memory lateralization in epilepsy patients. However, limited data are available on the reliability of this technique in clinical practice. This study aims to assess the robustness of the HTW paradigm for localising and lateralising memory function in a consecutive clinical series of 117 Temporal Lobe Epilepsy patients. Memory-related activation patterns were observed in 76% of cases with 94% reproducibility.
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