Keywords: Epilepsy, Quantitative Susceptibility mappingMagnetic susceptibility of subcortical grey matter regions was assessed in participants of the Australian Epilepsy Project pilot study. Adults with medication-resistant focal epilepsy were compared to those with newly-diagnosed focal epilepsy, and to people with a single seizure but no epilepsy diagnosis. Basal ganglia, thalamus, hippocampi and amygdala showed susceptibility values consistent with published values, with a positive correlation to age seen at the basal ganglia. There was no significant difference in subcortical susceptibility between the groups. Although other brain network changes may progress with refractory seizures, mineralisation of subcortical regions appears generally stable over the course of focal epilepsy.
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