Keywords: Brain Connectivity, COVID-19In the investigation of mental health issues following the unprecedented COVID-19 pandemic, we used the pre-COVID neuroimaging data to predict the severity of negative affect during the pandemic in a general population. Notably, covariation patterns of mode stress and mode anxiety were identified, and the brain DAN network plays a critical role in both modes. Based on individualized patterns, we may identify individuals who confer high vulnerability to pandemic-induced stress or anxiety symptoms. Our findings may facilitate the understanding of neural correlates underlying pandemic-induced negative affect, and the susceptibility neuromarkers may serve as targets for early prevention and psychological intervention.
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