Abstract #1031

Comparing Techniques for Multi-Site Harmonization of Structural Connectivity

Nancy Rose Newlin¹, Leon Cai², Derek Archer^3,4,5, Kimberly R Pechman³, Kurt G Schilling⁶, Angela Jefferson^3,5,7, Susan M Resnick⁸, Timothy J Hohman^3,4,5, Andrea Shafer⁹, and Bennett Landman^2,5,6,10

¹Computer Science, Vanderbilt University, Nashville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, United States, ⁵Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁷Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States, ⁸Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, ⁹Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, United States, ¹⁰Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: Brain Connectivity, Diffusion/other diffusion imaging techniquesTractography is a method to reconstruct white matter microstructure from DWI information and connectomics maps this reconstruction to a graph representation. We compute modularity, assortativity, global efficiency, and average betweenness centrality on this graph. We model changes in these measures with age and sex using DWI for healthy patients from two sites. Data from different sites requires harmonization to remove site-effects. We compare performances of ComBat and LinearRISH harmonization techniques at reducing CoV and removing confounding site-effects from associated linear models. We find that ComBat is effective at both and using LinearRISH in addition acts synergistically at harmonizing site differences.

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