Keywords: Brain Connectivity, fMRI (resting state), deep brain stimulation, memory, cognitionDeep brain stimulation (DBS) has been a well-established treatment for cognitive dysfunction. However, cognitive dysfunctions were demonstrated to be associated with the metabolic syndrome. Nucleus accumbens (NAc) in the dopaminergic pathway is associated with glucose metabolism, considered to be a promising DBS targeted region to be investigated. Resting-state functional MRI, behavioral test, bioenergetic analysis and electron microscopy were applied in this study. We found increased functional connectivity, enhancement in cognitive behavior, increased energy metabolism and mitochondrial biomass after NAc-DBS.
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