Abstract #1033

Zero echo time MB-SWIFT functional MRI of orientation selective deep brain stimulation of the rat infralimbic cortex using tetrahedral electrode

Hanne Laakso¹, Ekaterina Paasonen¹, Irina Gureviciene¹, Omar Narvaez¹, Lauri J Lehto¹, Jaakko Paasonen¹, Raimo Salo¹, Kestutis Gurevicius¹, Silvia Mangia², Shalom Michaeli², Heikki Tanila¹, Alejandra Sierra¹, and Olli Gröhn¹

¹A.I. Virtanen Institute, Kuopio, Finland, ²Center for Magnetic Resonance Research, Minneapolis, MN, United States

Synopsis

Keywords: Brain Connectivity, fMRI

In this study, the response of the amygdala to 3D orientation selective deep brain stimulation of the infralimbic cortex (IL) was followed using MB-SWIFT fMRI. The aims were to investigate how the fMRI response of the amygdala changes whilst changing the stimulation angle in the IL, and to detect the effects in resting-state functional connectivity when sustained 130 Hz stimulation of the IL at the most effective stimulation angle is used. The fMRI response of the amygdala showed dependence on the stimulation angle and inter-animal variation, which can be exploited for optimizing the stimulation effects.

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