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Abstract #1039

Towards microstructure-informed QSM: A digital phantom study

Anders Dyhr Sandgaard1, Valerij G. Kiselev2, Noam Shemesh3, and Sune Nørhøj Jespersen1,4
1Center for functionally integrative neuroscience, department of clinical medicine, Aarhus University, Aarhus, Denmark, 2Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, 3Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 4Department of Phsysics and Astronomy, Aarhus University, Aarhus, Denmark

Synopsis

Keywords: Susceptibility, Quantitative Susceptibility mappingMagnetic susceptibility can provide valuable information about chemical composition and microstructural organization in tissues. However, its estimation from the MRI signal phase is particularly difficult, as it depends on both magnetic tissue properties on all length scales. Here we investigate the feasibility of inverting our recently presented model of WM magnetic microstucture to estimate susceptibility. This is done on a digital brain phantom based on actual dMRI measurements of an ex-vivo mouse brain at ultra-high field.

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