Abstract #1041

Superconducting Quantum Interference Device (SQUID-) Based Susceptometry as a Reference Measurement for Quantitative Susceptibility Mapping

Gregory Simchick^1,2, Ronald T Wakai², Roland Fischer³, Oswaldo Baffa^2,4, Kevin Pratt⁵, Doug Paulson⁵, Scott B Reeder^1,2,6,7,8, and Diego Hernando^1,2

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁴Physics, University of Sao Paulo, Ribeirao Preto, Brazil, ⁵Tristan Technologies, Inc, San Diego, CA, United States, ⁶Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁷Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁸Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Validation, SusceptibilityMany quantitative susceptibility mapping (QSM) studies lack independent reference measurements of susceptibility (χ) for validation. In this work, superconducting quantum interference device (SQUID-) based susceptometry and QSM data were acquired for phantoms with varying manganese chloride (MnCl₂) concentrations. χ_SQUID demonstrated low uncertainty and excellent agreement with the nominal susceptibility values. χ_QSM and R2* agreed relatively well with the nominal values and previously published results. However, χ_QSM demonstrated higher uncertainty in comparison to χ_SQUID. SQUID susceptometry has the potential to identify sources of bias and variability in QSM methods by serving as an independent reference measurement of susceptibility.

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