Abstract #1046

Fast Submillimeter QSM for Simultaneous QSM/MRSI of the Brain at 7T

Rong Guo^1,2, Yudu Li^2,3, Yibo Zhao^2,4, Aaron Anderson², Pallab Bhattacharyya⁵, Mark Lowe⁵, Yao Li⁶, Brad Sutton^2,3,4,7,8, and Zhi-Pei Liang^2,3,4

¹Siemens Medical Solutions USA, Inc., Urbana, IL, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁶School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁷Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁸Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Susceptibility, Quantitative Susceptibility mappingThe feasibility of simultaneous QSM and MRSI has been recently demonstrated using SPICE. But the resolution of QSM obtained by SPICE at 7T is limited to only 3 mm due to bandwidth requirements. To overcome the resolution limitation, this work proposes a fast acquisition sequence for high-resolution encoding, and a model-based method to reconstruct from sparse sampling. As a result, submillimeter QSM can be achieved within only 1 minute, which enables simultaneous QSM (at 0.8 mm) and MRSI (at 3.0 mm) in an 8-minute scan at 7T.

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