Abstract #1049

Probing underlying biophysical mechanisms of electrical properties change by pathogenesis at the microscopic cellular level

Henghui Liu¹, Guofang Xu¹, Yinhao Ren¹, Feng Liu², Xiang Nan³, and Jijun Han¹

¹School of Biomedical Engineering, Anhui Medical University, Hefei, China, ²School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Australia, ³Department of Anatomy, Anhui Medical University, Hefei, China

Synopsis

Keywords: Electromagnetic Tissue Properties, LiverMagnetic resonance electrical properties tomography provides a non-invasive approach to extracting pixel-wise electrical properties by B1 field mapping. However, there is a void in our understanding of the underlying biophysical mechanism of electrical properties changes accompanied by pathogenesis at the microscopic cellular level. In this work, we build a microscopic tissue model to study fatty liver disease, which focuses on exploring the relationship between fat fraction and electrical properties. Our findings could bridge microscopic lesions and pixel-wise EPT images and may offer a novel strategy for retrieving electrical properties via fat quantification techniques such as Dixon directly.

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