Abstract #1053

Histological validation of myelin-sensitive MRI metrics in the common marmoset

Christopher D Rowley^1,2, Daryan Chitsaz², Ilana R. Leppert¹, Jennifer S.W. Campbell¹, Stephen Nuara³, Timothy E. Kennedy², G. Bruce Pike⁴, and Christine L. Tardif^1,2,5

¹McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada, ²Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, ³Comparative Medicine and Animal Resources Center, McGill University, Montreal, QC, Canada, ⁴Hotchkiss Brain Institute and Departments of Radiology and Clinical Neuroscience, University of Calgary, Calgary, AB, Canada, ⁵Department of Biomedical Engineering, McGill University, Montreal, QC, Canada

Synopsis

Keywords: Validation, Brain, Marmoset

Several studies have compared myelin-sensitive MRI maps to myelin staining to demonstrate the degree of correlation of the MRI metric with myelin content. This study in the common marmoset compares six myelin-sensitive MRI metrics acquired in vivo to stains for myelin, cell nuclei, and ferritin. T₂^*-based myelin water fraction (MWF) and inhomogeneous magnetization transfer saturation (ihMT_sat) presented the greatest specificity for myelin content, with ihMT_sat having a higher signal in grey matter regions. T₁w/T₂w had the strongest correlation with the iron-storage protein ferritin, and T₂^* presented the greatest correlation with the cell nuclei stain.

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