Abstract #1076

Toward accurate cerebral blood flow estimation in mice after accounting for anesthesia

Zhiliang Wei^1,2, Yuguo Li^1,2, Adnan Bibic², Jiadi Xu^1,2, and Hanzhang Lu^1,2,3

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Flow, AnimalsCBF measurements in mice were often confounded by the utilizations of anesthesia, which are generally vasoactive. Here, we aimed to systematically understand the relationships between CBF and related physiological factors, not only the anesthesia dose but also respiratory rate (RR), heart rate (HR), and exposure time to anesthesia. We found that CBF measurements in mice were affected by anesthesia dose and time, but can be corrected by using respiratory rate and heart rate. The correction scheme will facilitate applications of CBF measurements in mechanistic understanding of vascular diseases and preclinical therapeutic trials by providing anesthesia-independent CBF measurements.

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