Abstract #1085

Validation of Non-Invasive Relative Pressure Mapping by 4D Flow MRI in Aortic Dissection

Brandon K. Hardy¹, Judith Zimmermann², Nicholas S. Burris^1,3, Daniel B. Ennis⁴, David Marlevi^5,6, and David A. Nordsletten¹

¹Dept. of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ²Dept. of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Dept. of Radiology, University of Michigan, Ann Arbor, MI, United States, ⁴Dept. of Radiology, Stanford University, Stanford, CA, United States, ⁵Dept. Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, ⁶Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Quantitative Imaging, Blood vessels, Pressure Estimation

False lumen (FL) growth rate in type B aortic dissection (TBAD) is correlated with FL pressurization. 4D flow MRI allows for quantitative assessment of three-dimensional flow, including spatial mapping of relative pressure. Despite its promise, 4D flow relative pressure mapping has not yet been validated in a TBAD-specific context. Here, we validate a state-of-the-art proposed Stokes Estimator (STE) of relative pressure against catheter measurements using three physiologically accurate TBAD flow phantoms and subsequently analyze the method’s sensitivity to image noise. STE pressure estimates closely matched catheter data and were robust to noise, indicating STE’s potential for TBAD treatment planning.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.