Abstract #1099

Initial Demonstration of Simultaneous Estimation of Water-Specific T1, PDFF, R2*, and QSM in the Liver Using Free-Breathing GraspT1-Dixon MRI

Jingjia Chen¹, Ding Xia², Kai Tobias Block³, Chunlei Liu¹, and Li Feng²

¹Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United States, ²Biomedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Center for Advanced Imaging Innovation and Research (CAI2R), NYU Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Quantitative Imaging, Multi-ContrastThis work demonstrates the feasibility of simultaneous estimation of fat/water-separated T1, proton density fat fraction (PDFF), R2*, and quantitative susceptibility mapping (QSM) of the liver using free-breathing GraspT1-Dixon MRI from a single rapid acquisition with an inversion-recovery (IR)-prepared multi-echo stack-of-stars sequence. For fat/water-separated T1 mapping, water-only images are generated from multi-echo images at different inversion times (TIs), from which a water-specific T1 map is estimated. For other parameters, acquired data from all TIs are averaged to generate a single set of multi-echo images, from which PDFF, R2*, and QSM are estimated.

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