Keywords: Quantitative Imaging, Contrast Agent, MR-STAT; Contrast Enhancement ImagingGadolinium-based contrast agents (GBCAs) uptake has the ability to facilitate disease diagnosis. In this work, we implement MR-STAT for fast contrast agent uptake quantification by applying keyhole acquisition and regularized reconstruction. We first analyze the accuracy of the proposed method on gadolinium-doped gel phantoms and observe that accurate T1 mapping of post-injection can be achieved with a keyhole factor of 25%. Furthermore, we investigate the impact of lower (20% vs 100%) GBCA dose administration on simulated clinical data. The quantification of pathologic T1 change for low-dose administration was comparable to that for full-dose.
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