Abstract #1115

Assessment of knee cartilage strain using the magnetization transfer ratio and T2: an ex vivo study at 9.4T MRI

Emily Sullivan^1,2, Andrew Yung³, Jessica Küpper^2,4, Kirsten Bale³, Piotr Kozlowski³, and David Wilson^2,4

¹School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada, ²Centre for Hip Health and Mobility, University of British Columbia, Vancouver, BC, Canada, ³UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁴Orthopaedics, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Cartilage, OsteoarthritisThe magnetization transfer ratio (MTR) was investigated as an alternative biomarker for cartilage strain compared to T2. Six ex vivo bovine knee specimens were compressed in a 9.4T scanner and scanned at several physiological step loads. Average strain, MTR, and T2 were calculated for each voxel column throughout the full depth of cartilage, and depth-dependent trends were identified. ΔMTR changed uniformly across the cartilage volume with strain, while ΔT2 showed a more localized yet inconsistent response. This suggests that MTR may be more sensitive in measuring cartilage strain in clinical applications where image resolution is lower.

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