Abstract #1117

Layers-Based Analysis of Knee Articular Cartilage: Comparing T1ρ Imaging Against Quantitative Susceptibility Mapping at 3 Tesla

ALLEN A CHAMPAGNE¹, TAYLOR M ZULEGER^2,3,4,5, DANIEL R SMITH^2,4,5, ALEXIS B SLUTSKY-GANESH^2,4,5,6, SHAYLA M WARREN^2,4,5, LEXIE M SENGKHAMMEE^2,4,5, SAGAR MANDAVA⁷, HONGJIANG WEI⁸, DAVIDE D BARDANA⁹, GREG D MYER^2,4,5,10, and JED A DIEKFUSS^2,4,5

¹School of Medicine, Queen's University, Kingston, ON, Canada, ²Emory Sports Performance And Research Center, Flowery Branch, GA, United States, ³Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH, United States, ⁴Emory Sports Medicine Center, Atlanta, GA, United States, ⁵Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA, United States, ⁶Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, United States, ⁷GE Healthcare, Atlanta, GA, United States, ⁸School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁹Department of Orthopaedics, Queen's University, Kingston, ON, Canada, ¹⁰The Micheli Center for Sports Injury Prevention, Waltham, MA, United States

Synopsis

Keywords: Cartilage, Microstructure, Quantitative Susceptibility Mapping, T1rho, kneeThe vertical microstructural organization of articular cartilage varies in its arrangement of collagen fibers, as well as the relative proteoglycan content. Knee osteoarthritis (OA) involves an inflammatory degenerative process that leads to depth-wise degeneration of the cartilaginous matrix. While quantitative MR protocols have emerged to evaluate proteoglycan content (T1ρ) and microstructural integrity (Quantitative Susceptibility Mapping; QSM), advances in layer-based analyses (e.g., superficial vs. deep) are warranted to identify the progression of diseased cartilage. We demonstrate the integrated utilization of QSM and T1ρ for characterizing depth-specific microstructural arrangement of articular cartilage, including differences in tissue organization and composition, respectively.

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