Abstract #1119

Novel 3D Quantitative Magnetization Transfer Imaging of The Whole Knee Cartilage

Albert Jang^1,2, Zachary Stewart², Martin Torriani², Miho Tanaka³, and Fang Liu^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States, ²Radiology, Massachusetts General Hospital, Boston, MA, United States, ³Orthopedic Surgery, Massachusetts General Hospital, Boston, MA, United States

Synopsis

Keywords: Cartilage, Magnetization transferWe propose to characterize cartilage extracellular matrix of the whole knee using a novel quantitative magnetization transfer (MT) imaging technique. This new technique achieves accurate T₁ and MT quantification by using a new sequence incorporating off-resonance RF pulses that create two simultaneous effects: 1) Bloch-Siegert phase shift to measure and correct for B₁⁺ inhomogeneity and 2) direct saturation of macromolecules to model MT. This new method, termed BTS (Bloch-Siegert and magnetization Transfer Simultaneously), is presented and validated in both phantom and in-vivo knee imaging experiments.

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