Abstract #1129

7T MR DTI and Tractography of a 1-Week Postmortem Fixed Human Brainstem-Cerebellum: Novel Imaging Methodology Producing Extraordinary Images

Sahin Hanalioglu¹, Giancarlo Mignucci-Jiménez², Siyar Bahadir¹, Alberto Fuentes³, Ethan Mathew³, Gregory Turner³, and Mark C Preul²

¹Department of Neurosurgery, Hacettepe University, Ankara, Turkey, ²Department of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, United States, ³Barrow Neurological Institute, Phoenix, AZ, United States

Synopsis

Keywords: White Matter, Diffusion Tensor Imaging, 7T MRI, Tractography, Connectivity, PostmortemDiffusion-tensor imaging (DTI) is routinely used to estimate the pattern, orientation, and directionality of white matter tracts in human living subjects. However, diffusion imaging of ex-vivo brain specimens is complex due to the diffusivity properties of fixed brain tissue. We developed a novel methodology for tractography of a 1-week postmortem fixed human brainstem and cerebellum specimen utilizing a deterministic fiber tracking algorithm on a 7T MR DTI diffusion scheme registered to an MNI space through landmark-based affine registration. The results showed highly detailed tractography images and agreement between left and right crossing and non-crossing fibers.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.