Abstract #1130

Tractwise perfusion-microstructure relationships in the aging white matter based on the Lifespan Human Connectome Project - Aging

Tyler D. Robinson¹, Yutong L. Sun¹, Paul T. H. Chang¹, and J. Jean Chen^1,2,3

¹Rotman Research Institute, Baycrest, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: White Matter, PerfusionThis study examined baseline and age-related differences in white matter perfusion and microstructural integrity across ten tracts of interest using 535 adult subjects of the Human Connectome Project in Aging. Whole-brain and tractwise relationships were identified between age, cerebral blood flow, mean diffusivity, and fractional anisotropy. Additionally, regional differences in age-related perfusion and microstructural trajectories were identified, representing one of the first direct examinations of regional variation in white matter perfusion in aging.

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