Keywords: White Matter, Relaxometry
Hypertension is a major risk factor for a myriad of neurodegenerative diseases. However, the effect of hypertension on cerebral microstructure, especially myelination, remains poorly understood. We employed multicomponent MR relaxometry and DTI to investigate the association between hypertension and cerebral microstructural integrity, with a focus on myelin content, in a cohort of cognitively unimpaired adults. Our results indicate that adults with hypertension exhibit significantly lower cerebral microstructural integrity and axonal myelination as compared to controls across, several white matter structures.
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