Keywords: White Matter, Multiple Sclerosis, Myelin water imaging, water content
We established a new in-vivo measurement of the myelin water gap that can serve as a biomarker for myelination packing. In postmortem studies, it was shown that the water layer gap between healthy myelin membranes is compact. However, it changes during the demyelination and remyelination processes in MS patients. We developed a biophysical model based on the water fraction and multi-compartment T2 to estimate the water gap. Next, we designed a lipid phantom system with varying water gaps and validated it using Cryo-TEM. Our model successfully estimates the water gap in-vitro and shows a reliable estimation for in-vivo healthy volunteers.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords