Abstract #1138
Assessing microstructural and microvascular abnormalities in hospitalized COVID-19 patients using intravoxel incoherent motion imaging
Noa van der Knaap1,2,3, Simona Klinkhammer1,4, Alida A. Postma1,3, Arjen J.C. Slooter5,6, Janneke Horn7,8, Caroline M. van Heugten4,9, Paulien H.M. Voorter1,3, Merel M. van der Thiel1,3, Gerhard S. Drenthen1,3, Walter H. Backes1,3, David E.J. Linden1, Marcel J.H. Ariës1,2, and Jacobus F.A. Jansen1,3,10
1School for Mental Health & Neuroscience, Maastricht University, Maastricht, Netherlands, 2Department of Intensive Care, Maastricht University Medical Center, Maastricht, Netherlands, 3Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 4Limburg Brain Injury Center, Maastricht University, Maastricht, Netherlands, 5Department of Intensive Care, University Medical Center Utrecht, Utrecht, Netherlands, 6UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands, 7Department of Intensive Care, University Medical Center Amsterdam, Amsterdam, Netherlands, 8Amsterdam Neuroscience, University Medical Center Amsterdam, Amsterdam, Netherlands, 9Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, Netherlands, 10Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands
Synopsis
Keywords: Infectious disease, COVID-19
Cerebral abnormalities are common in (severely affected) COVID-19 patients, although most reports only cover macrostructural abnormalities. Zooming in on microstructural abnormalities may better explain persisting COVID-19-related symptoms in COVID-19 survivors. Using intravoxel incoherent motion (IVIM) imaging, this study explored potential differences in microstructural and microvascular diffusivity between COVID-19 patients. No differences were found between patients admitted to the intensive care unit (ICU) (n=40) and general ward (n=38). However, increased disease severity in COVID-19 ICU patients was found to be associated with increased interstitial fluid content in the normal appearing white matter.
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