Abstract #1139

Quantitative diffusion and Kurtosis MRI in the evaluation of endometrial cancer: validation with histopathology

Alessandra Maiuro^1,2, Francesca Di Stadio², Serena Satta³, Giorgia Perniola⁴, Innocenza Palaia⁴, Angelina Pernazza³, Carlo Della Rocca³, Carlo Catalano³, Lucia Manganaro³, and Silvia Capuani^1,2

¹Physics, CNR Institute for Complex Systems (ISC), Rome, Italy, ²Physics, Sapienza University of Rome, Rome, Italy, ³Radiological, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy, ⁴Maternal and Child Health and Urological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy

Synopsis

Keywords: Pelvis, Cancer, Pelvis, Endometrium, Endometrial cancer, IVIM, KurtosisTo ameliorate the Endometrial cancer (EC) diagnosis and prognosis, IVIM and KURTOSIS models were used to elaborate DWIs obtained from 18 with EC and 20 healthy women. The b-values were 0,30,50,150,500,800,1000,1500,2000,2500s/mm2. DWIs were noise-corrected considering a homomorphic approach. For each EC subject, ROI in the tumor (T) and peritumoral (PT) area were analysed and endometrial area in healthy (H) subjects was also obtained. IVIM and Kurtosis parameters were quantified. K, which quantifies tissue’s complexity, is significantly higher in T and PT than in H. f is higher in PT compared to the other areas, highlighting the perfusive nature of EC.

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