Abstract #1141

Widespread, depth-dependent microstructural damage in the cortex of children with focal epilepsy: A quantitative T1 and T2 mapping study

Chiara Casella¹, Katy Vecchiato^1,2, Daniel Cromb¹, Yourong Guo¹, Emer Hughes¹, Louise Dillon¹, Elaine Green¹, Kathleen Colford¹, Anthony Price¹, Lucilio Cordero Grande^3,4,5,6, Tobias C. Wood⁷, Shaihan Malik³, Rui Pedro A. G. Teixeira³, David W. Carmichael³, and Jonathan O'Muircheartaigh^1,2,8

¹Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, ³Department of Biomedical Engineering, King's College London, London, United Kingdom, ⁴Biomedical Image Technologies, ETSI Telecomunicación, Madrid, Spain, ⁵Universidad Politécnica de Madrid, Madrid, Spain, ⁶Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain, ⁷Department of Neuroimaging, King's College London, London, United Kingdom, ⁸MRC Centre for Neurodevelopmental Disorders, London, United Kingdom

Synopsis

Keywords: Epilepsy, Relaxometry, Paediatric

We assessed cortical microstructure in children with drug-resistant focal epilepsy using T1 and T2 relaxometry (qT1 and qT2). We show widespread, depth-mediated qT1 and qT2 increases, and alterations in intracortical organisation in patients. Changes did not correlate with clinical parameters, suggesting that they may be independent of disease severity. Using a random forest algorithm, we also show that qT1 and qT2 surface-features from patients with radiologically defined abnormalities (MRI-positive) and controls, can classify patients without reported radiological abnormalities (MRI-negative). This suggests a common imaging endophenotype of focal epilepsy irrespective of visible abnormalities that may be present at a pre-symptomatic disease-stage.

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