Abstract #1145

Investigating spinal cord perfusion impairment in degenerative cervical myelopathy (DCM) using Intravoxel Incoherent Motion (IVIM) MRI

Anna Lebret¹, Simon Lévy², Nikolai Pfender¹, Mazda Farshad³, Virginie Callot^4,5, Armin Curt¹, Patrick Freund^1,6, and Maryam Seif^1,6

¹Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland, ²MR Research Collaborations, Siemens Healthcare Pty Ltd, Melbourne, Australia, ³Department of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, Zurich, Switzerland, ⁴Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, ⁵APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ⁶Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Synopsis

Keywords: Spinal Cord, Neurodegeneration, Degenerative Cervical MyelopathyDegenerative cervical myelopathy (DCM) is the most common form of non-traumatic spinal cord injury, mainly caused by chronic cervical cord compression. Impaired spinal cord perfusion is a central pathophysiological tenet in DCM patients. This study aims at investigating non-invasively DCM-induced changes of blood perfusion in the spinal cord above a cervical myelopathy using quantitative MRI techniques. Cardiac-gated intravoxel incoherent motion (IVIM) 3T MRI, sensitive to perfusion, was applied to the cervical cord (C1-C3) in 25 DCM patients and 27 healthy controls. DCM showed tissue-specific perfusion impairment. IVIM maps suggested remote hemodynamic deficit induced by cervical cord compression in DCM.

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