Abstract #1153

Optimized Flow Compensation for Wave-CAIPI Post-Contrast 3D-T1 MPRAGE

Min Lang¹, Azadeh CD Tabari¹, Komal Awan¹, Wei Liu², Clifford Bryan³, Wei-Ching Lo³, Daniel Nicolas Splitthoff⁴, Stephen Cauley¹, Huang Susie¹, and Conklin CD John¹

¹Massachusetts General Hospital, Boston, MA, United States, ²Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ³Siemens Medical Solutions USA, Boston, MA, United States, ⁴Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Keywords: Artifacts, Data Acquisition, MR Value, Clinical Application, Neuro, Artifacts, Flow, Data AcquisitionFlow-related artifacts have been consistently observed in highly accelerated Wave-CAIPI post-contrast 3D-T1 MPRAGE and have an atypical appearance. Such artifacts introduce a diagnostic conundrum as they can mimic enhancing lesions and may require callback for repeat imaging, posing a critical barrier to wider clinical adoption of this technique. To address this, we developed an optimized flow-mitigated Wave-CAIPI post-contrast 3D T1 MPRAGE acquisition, tested it in a novel flow phantom, and deployed it in 17 patients undergoing contrast-enhanced brain MRI. Flow-mitigation was successful at reducing flow-related artifacts in most cases without sacrificing SNR, gray-white matter contrast, or enhancing lesion conspicuity.

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