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Abstract #1175

Towards whole brain mapping of the hemodynamic response function

Maria Guidi1, Fabio Mangini1,2, Marta Moraschi1,3, Daniele Mascali1,3, Michela Fratini3,4, Silvia Mangia5, Fabrizio Frezza2, and Federico Giove1,3
1MARBILab, Enrico Fermi Research Center, Rome, Italy, 2Sapienza University, Rome, Italy, 3Fondazione Santa Lucia IRCCS, Rome, Italy, 4CNR-NANOTEC, Rome, Italy, 5CMRR, Minneapolis, MN, United States

Synopsis

Keywords: Signal Modeling, fMRI, HRFWe characterized a deconvolved haemodynamic response function (dHRF) across the whole cortex exploiting a sine series expansion in a cohort of young healthy subjects from the Human Connectome Project. We report, for different tasks and brain regions, the amplitude, latency, time-to-peak and full-width at half maximum of the fitted BOLD response and of the dHRF. We show that each of those parameters vary throughout the cortex and, to a smaller extent, across subjects. Additionally, the use of a flexible model, like the one we explored in this study, reveals that the HRF in some brain regions deviates from canonicity.

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