Abstract #1176

Integrated heart-brain 4D flow MRI evaluation of hemodynamic coupling in healthy aging adults

Adam Richter¹, Jackson E. Moore¹, Maria Aristova¹, Ann Ragin¹, Susanne Schnell², Emily Rogalski³, Michael Markl¹, and Kelly Jarvis¹

¹Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ²Department of Medical Physics, Institute of Physics, University of Greifswald, Greifswald, Germany, ³Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, United States

Synopsis

Keywords: Data Analysis, Velocity & Flow, Cerebral arteries

Age-related changes in cardiovascular hemodynamics may be associated with brain changes. However, this relationship is not clear since blood flow in the heart and brain are usually imaged and analyzed in separate exams and pipelines. We have developed a technique for parameter mapping in both the aorta and intracranial vessels to allow for integrated MRI evaluation of heart-brain hemodynamic coupling. This study demonstrates a single MRI study and analysis pipeline to facilitate more comprehensive, integrated heart-brain hemodynamic analysis in clinical and research settings.

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