Abstract #1177

Capillary-weighted velocity-selective ASL for subsecond fast fMRI

Daniel E. P. Gomez^1,2,3, Laura D. Lewis^1,3, Jonathan R. Polimeni^1,2,4, and Divya S. Bolar⁵

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Biomedical Engineering, Boston University, Boston, MA, United States, ⁴Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁵Center for Functional Magnetic Resonance Imaging, Department of Radiology, University of California San Diego, La Jolla, CA, United States

Synopsis

Keywords: Data Acquisition, fMRIThis work evaluates capillary-weighted VS-ASL for subsecond functional cerebral blood flow (CBF) mapping with high microvascular specificity. Three experiments were conducted: one to demonstrate that capillary-weighted VS-ASL is mostly free from macrovascular contamination when compared to arterial-weighted VS-ASL, one to demonstrate that functional MRI is feasible with capillary-weighted VS-ASL at moderate repetition times, and one to show that, despite lower sensitivity, capillary-weighted functional MRI can be performed at subsecond temporal resolution. Our findings suggest that capillary-weighted VS-ASL may enable the study of fast functional CBF responses with high neuronal specificity.

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