Abstract #1178

Test-Retest Reliability of 3D Velocity-Selective Arterial Spin Labeling for Detecting Normal Variations of Cerebral Blood Flow

Feng Xu^1,2, Dapeng Liu^1,2, Dan Zhu^1,2, Argye E. Hillis³, Arnold Bakker⁴, Anja Soldan³, Marilyn Albert³, Doris D. M. Lin¹, and Qin Qin^1,2

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Data Acquisition, Arterial spin labelling Velocity selective inversion (VSI) based velocity selective arterial spin labeling (VSASL) was recommended by a recent guideline paper. We conducted a test-retest study to evaluate the reliability of 3D VSI-VSASL. The correlations between repeated measures were 0.94/0.81 (within- /between-session) for individual absolute CBF and 0.99/0.98 for regional relative CBF. The intraclass correlation coefficients were 0.88/0.77 for absolute CBF and 0.92/0.85 for regional relative CBF. Between-subject variation in CBF was partially contributed by age and physiological parameters. VSI-VSASL demonstrates moderate to excellent reliability for detecting between-subject and between-region variations among healthy subjects, suggesting its merit in clinical applications.

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