Abstract #1182

Age-related Vascular Changes in Choroid Plexus Evaluated Using High-resolution USPIO-Enhanced 7T MRI

Zhe Sun^1,2, Chenyang Li^1,2, Marco Muccio¹, Li Jiang¹, and Yulin Ge¹

¹Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Neurofluids, AgingThe choroid plexus (ChP) is a highly vascularized structure that is important in CSF production and waste solute clearance. In this work, USPIO-enhanced 7T imaging was used to detect microvascular changes associated with normal aging. We showed improved susceptibility contrast of ChP vessels and surrounding stromal tissues on high-resolution USPIO-enhanced 2D T2*-weighted MRI. Both age-related sparser vasculature and distended stromal tissues were identified. ChP volume increases with age, whereas the difference between pre-/post-contrast quantitative susceptibility map (QSM) decreases with age (P<0.05); and vascular degenerative change may occur earlier than volume change.

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