Abstract #1183

Quantitative Flow Velocity in Cerebral Perforating Arteries with 7T MRI: the EUFIND study.

Stanley D.T. Pham¹, Jari T. van Vliet², Rick J van Tuijl², Geert Jan Biessels³, Mauro Costagli⁴, Mark A. van Buchem⁵, Oliver Kraff⁶, Arno Villringer⁷, Mark E. Ladd⁸, Jeroen C.W. Siero^2,9, Ludovic de Rochefort¹⁰, and Jaco J.M. Zwanenburg²

¹UMC Utrecht, Utrecht, Netherlands, ²Radiology, UMC Utrecht, Utrecht, Netherlands, ³Neurology, UMC Utrecht, Utrecht, Netherlands, ⁴IMAGO7 Research Foundation, Pisa, Italy, ⁵Neuroradiology, Leiden University Medical Center, Leiden, Netherlands, ⁶Radiology, University Hospital Essen, Essen, Germany, ⁷Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁸German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁹Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, ¹⁰Centre for Magnetic Resonance in Biology and Medicine (UMR 7339), Marseille, France

Synopsis

Keywords: Data Acquisition, High-Field MRI, Harmonization, two dimensional phase contrastWe analyzed multi-center blood flow velocity measurements in perforating arteries from 7T MRI with the two-dimensional phase-contrast (2D-PC) sequence (eight sites, comprising three MRI vendors). Analysis was performed with the software tool Small vessEL MRI MArkers (SELMA). Inter-rater reliability of SELMA was excellent with overall intra-class coefficients for number of vessels (N_detected), mean velocity (V_mean) and velocity pulsatility index (vPI) of at least 0.84 for 2D-PC data from all MRI vendors. Inter-vendor differences were larger than the intra-vendor differences (coefficients of variation: 0.62 vs. 0.39, 0.21 vs. 0.12 and 0.39 vs. 0.12 for N_detected, V_mean and vPI, respectively).

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