Abstract #1184

Hybrid multi-delay PCASL of time-encoded and variable-TR schemes for the assessment of cerebral perfusion in Moyamoya disease

Osamu Togao¹, Makoto Obara², Koji Yamashita³, Kazufumi Kikuchi⁴, Tatsuhiro Wada⁵, Chiaki Tokunaga⁵, Ryoji Mikayama⁵, Shota Ishida⁶, Hiroshi Hamano², Lena Vaclavu⁷, Matthias J.P. van Osch⁷, Kim van de Ven⁸, Marc Van Cauteren², and Kousei Ishigami⁴

¹Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ²Philips Japan, Tokyo, Japan, ³Departments of Radiology Informatics and Network, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁴Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁵Division of Radiology, Department of Medical Technology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁶Department of Radiological Technology, Faculty of medical sciences, Kyoto College of Medical Science, Kyoto, Japan, ⁷C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁸Philips Healthcare, Best, Netherlands

Synopsis

Keywords: Stroke, Perfusion, Arterial Spin LabelingWe have developed a multi-delay PCASL acquisition with a hybrid scheme, combining time-encoded and variable-TR schemes. This hybrid scheme combines the advantage of high SNR obtained with the time-encoded scheme with the timing flexibility of the variable-TR scheme. We investigated the abilities for CBF (cerebral blood flow) and ATT (arterial transit time) quantification in Moyamoya disease. The hybrid scheme provided a higher temporal SNR than the other two schemes. Although slight differences in the CBF and ATT measurements were found between the hybrid and the other two schemes, the differences were acceptable, considering the strong correlations and excellent agreements.

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