Abstract #1185

Clinical feasibility of contrast-enhanced ASL for blood-brain barrier water exchange rate measurements

Elizabeth Powell¹, Ben Dickie^2,3, Yolanda Ohene^2,3, Geoff JM Parker^1,4,5, and Laura M Parkes^2,3

¹Centre for Medical Image Computing, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom, ³Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ⁴Queen Square MS Centre, Institute of Neurology, University College London, London, United Kingdom, ⁵Bioxydyn Limited, Manchester, United Kingdom

Synopsis

Keywords: Quantitative Imaging, Neurofluids, Blood-brain barrier water exchange

Contrast-enhanced ASL (CE-ASL) has been proposed as a method for measuring blood-brain barrier water exchange, and is a technique that could be used in conjunction with DCE/DSC-MRI to provide complementary information on brain vasculature.

We demonstrate in this work the clinical feasibility and consistency of the CE-ASL technique in simulations and in healthy volunteers. Using simulations, we characterise the expected accuracy and precision of parameter estimates. We then evaluate the consistency of CE-ASL measurements across six healthy volunteers.

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