Abstract #1190

In vivo multimodal MRI of the healthy optic nerves

Antonio Ricciardi¹, Marios C. Yiannakas¹, Ratthaporn Boonsuth¹, Rodas Ghilom Bogatsion¹, Claudia A. M. Gandini Wheeler-Kingshott^1,2,3, and Rebecca S. Samson¹

¹NMR Research Unit, Queen Square Multiple Sclerosis Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ²Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ³Brain Connectivity Research Center, IRCCS Mondino Foundation, Pavia, Italy

Synopsis

Keywords: Nerves, Quantitative ImagingThe optic nerve (ON) is implicated in a variety of neurological disorders but is challenging to study through magnetic resonance imaging due to its small size and jittering. In this study, we developed an acquisition protocol and analysis pipeline that enables to produce quantitative proton density (PD), macromolecular tissue volume (MTV), T2* and T1 maps of the ON from a 20-minute scan. Results show good scan-rescan reproducibility of ON values, and agreement with regional brain values. Significant differences in PD, MTV and T1 were observed between left-right ON measures, and left-right fronto-temporal white matter, which warrant further investigation.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.