Abstract #1194

MRI Assessment of the Therapeutic Effect of Combined Electroacupuncture and Stem Cells in Acute Peripheral Nerve injury

yueyao chen¹, zhongxian pan¹, fanqi meng¹, xuewen yu², qian xu¹, leyu huang¹, qiumei liang¹, yanglei wu³, hanqing lyu¹, and xiaofeng lin⁴

¹Department of radiology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China, ²Department of pathology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China, ³MR Collaboration, SIEMENS Healthineers Ltd., Beijing, China, ⁴Department of Nuclear Medicine, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China

Synopsis

Keywords: Nerves, Nervous system, Electroacupuncture, Mesenchymal stem cellsWe aimed to verify the efficacy of bone mesenchymal stem cells (BMSCs) combined with electroacupuncture (EA) in the treatment of peripheral nerve injury (PNI) using pathology and MRI. In a rat model of sciatic nerve crush damage, we found that BMSCs and EA combined therapy improved axon and myelin regeneration synergistically and significantly decreased post-injury nerve edema, improved axon guiding factor, and expedited motor function recovery. This suggests that a combination of BMSCs and EA can provide both topological and biomolecular guidance to promote axonal extension, myelin regeneration, and functional recovery after PNI.

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