Abstract #1195

Altered white matter diffusion properties and gray matter volume in classical trigeminal neuralgia

Yang Zhang¹, Wei Su², Xiaoyu Du³, Rui Li⁴, Hang Zhao⁴, Zhaoping Wang¹, Lei Feng¹, liangjie lin⁵, and Kaihua Zhang²

¹Department of Neurosurgery, Jining No. 1 People’s Hospital, Jining, China, ²School of Psychology, Shandong Normal University, Ji’nan, China, ³Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Victoria, Australia, ⁴Department of Radiology, Jining No. 1 People’s Hospital, Jining, China, ⁵Clinical and Technical Support, Philips Healthcare, Beijing, China

Synopsis

Keywords: Nerves, Diffusion Tensor Imaging, Trigeminal neuralgia, trigeminal nerve fiberInvestigating microstructural changes in patients with classical trigeminal neuralgia (CTN) has contributed to understanding the pathological neural mechanism of CTN. This study aimed to reveal abnormalities of the trigeminal fiber bundles by combing MR diffusion tensor imaging (DTI) with voxel-based morphometry (VBM). 32 patients with CTN and 32 matched healthy controls were recruited with the main fiber bundle diffusion indices calculated and the whole-brain gray matter volume measured for each subject. Results showed that CTN exhibited microstructural changes in the trigeminal nerve fibers, and the changes might be associated with the pathogenesis of trigeminal neuralgia.

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