Abstract #1197

Associations Between Central Canal Stenosis, Resting State Functional Connectivity Networks, and Pain Perception

Jennifer Anne Cummings¹, Madeline Hess¹, Kenneth Gao¹, Upasana Bharadwaj¹, Misung Han¹, Cynthia Chin¹, Salvatore Torrisi¹, Jennifer Townsend¹, An Vu¹, Valentina Pedoia¹, and Sharmila Majumdar¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Nerves, Nervous systemChronic lower back pain remains difficult to characterize with imaging. With this study, we investigate the relationship between imaging-based brain and spine biomarkers in pain perception. We present relationships between resting state functional connectivity networks, automatic spinal canal stenosis grading, and patient-reported pain measures. Patients reporting severe pain show weaker connectivity in the Left Ventral Attention Network and stronger connectivity within the Salience network when compared to those reporting no pain or mild/moderate pain. The severe back pain group also shows a higher spinal canal stenosis grading.

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