Keywords: Nerves, fMRI (resting state)Disrupted neurovascular (NV) coupling is considered as a potential mechanism of Type 2 diabetes mellitus (T2DM) induced mild cognitive impairment (MCI). The study quantitatively explored whether NV decoupling were associated with cognitive impairment in patients with T2DM by means of neuroimaging meta-analysis and an independent validation. In T2DM, NV uncoupling existed in many brain regions, and the degree of uncoupling was related to cognition. It contributed to a better understanding of the mechanism in T2DM cognitive impairment and would be a promising neuroimaging biomarker. This study combined meta-analysis and independent validation model can be extended to other similar studies.
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