Abstract #1208

Hyperpolarized xenon-129 dissolved MRI based on two-point Dixon method

Hengjie Chen¹, Jaime F Mata², Y. Michael Shim², John P. Mugler², Xiaoping Hu¹, Li Zhao³, An Liu⁴, and Kun Qing^1,4

¹University of California, Riverside, Riverside, CA, United States, ²University of Virginia, Charlottesville, VA, United States, ³Zhejiang University, Hangzhou, China, ⁴City of Hope National Medical Center, Duarte, CA, United States

Synopsis

Keywords: Lung, Hyperpolarized MR (Gas)In this work, a 2-point Dixon-based method is developed to provide separation of the hyperpolarized xenon-129 dissolved-phase magnetic resonance imaging (MRI) components for pulmonary applications. Based on analysis of data from 6 healthy volunteers and 20 patients with lung disease, the separated tissue and red blood cell (RBC) components obtained from this method are highly consistent with those from the previously-described 3-point Dixon method. The 2-point Dixon based method has the potential to greatly improve the signal-to-noise ratio for dissolved-phase MRI while still maintaining accurate tissue/RBC separation.

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