Keywords: Lung, Perfusion
Quantitative pulmonary perfusion can be derived from MR imaging with injection of contrast agent (CA). Tracer-kinetic theory yields physiological parameters such as pulmonary blood flow (PBF), blood volume (PBV) and mean transit time (MTT) but relies on accurate calculation of CA concentration. Previous studies have used ‘subtraction’ or ‘normalisation’ methods without T1-mapping. Using both simulations and data from interstitial lung disease patients, we demonstrate how the ‘subtraction’ method weights PBV by local lung density. This causes likely spurious correlations with hyperpolarised 129Xe biomarkers linked to lung ventilation, microstructure and density, potentially obscuring information of diagnostic interest.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords