Abstract #1224

The value of glucose-chemical exchange saturation transfer and amide proton transfer in predicting tumor grading and staging in rectal cancer

Han Jiang¹, Nan Meng², Ziqiang Li¹, Bo Dai², Pengyang Feng³, Yu Luo², Zhiwei Shen⁴, and Meiyun Wang*²

¹Department of Medical Imaging, XinxiangMedical University & Henan Provincial People's Hospital, Zhengzhou, China, ²Department of Medical Imaging, Zhengzhou University People's Hospital & Henan Province People's Hospital, Zhengzhou, China, ³Department of Medical Imaging, Henan University People’s Hospital & Henan Provincial People’s Hospital, Zhengzhou, China, ⁴Philips healthcare, Beijing, China

Synopsis

Keywords: Pelvis, CEST & MT, rectal cancerWhat are the values of glucose-chemical exchange saturation transfer (glucoCEST) and amide proton transfer (APT) imaging in WHO grading and T staging of rectal cancer? We performed 3D-glucoCEST, 3D-APT, and DWI scans in 21 rectal adenocarcinoma cases. GlucoCEST signal intensity (SI) and 3D-APT SI could distinguish high-grade from low-grade, and T3 stage from T2 stage rectal adenocarcinoma, and both had comparable diagnostic efficacy. In addition, 3D-glucoCEST SI and 3D-APT SI were positively correlated with tumor grade.

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