Abstract #1247

Motion-corrected free-running 4D MRI of the fetal heart - from in silico to in vivo

Robin Ferincz¹, Mariana Baginha Da Lanca Falcão¹, Aurelio Secinaro², Guido Buonincontri³, Leonor Alamo⁴, Estelle Tenisch⁴, Milan Prša⁵, Davide Piccini^1,6,7, Jérôme Yerly⁸, Matthias Stuber⁸, and Christopher William Roy¹

¹Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ²Advanced Cardiothoracic Imaging Unit, Department of Imaging, Bambino Gesù Children’s Hospital IRCCS, Rome, Italy, ³Siemens Healthcare srl, Milan, Italy, Milan, Italy, ⁴Department of Radiology and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁵Woman- Mother-Child Department, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁶Advanced Clinical Imaging Technology (ACIT), Siemens Healthineers International AG, Lausanne, Switzerland, ⁷LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁸Center for Biomedical Imaging (CIBM), Lausanne, Switzerland

Synopsis

Keywords: Fetal, CardiovascularMR imaging of the fetal heart is challenging due to resolution requirements and the impact of maternal respiration, fetal cardiac motion, and gross fetal movement. These factors have largely precluded the development of 3D acquisition techniques. In this work, a novel reconstruction algorithm is developed to estimate and correct for displacement of the fetal heart due to maternal respiration and gross fetal movement enabling the first-ever motion-corrected time-resolved 4D images of the fetal heart from 3D radial data. Proof-of-concept results are demonstrated using a comprehensive numerical simulation developed for this work and initial data acquired in utero.

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