Abstract #1249

Can MRS detect metabolites differences in fetuses affected by CMV?

Or Rachel Sadan^1,2, Netanell Avisdris^2,3, Aviad Rabinowich^2,4,5, Daphna Link-Sourani², Liat Ben Sira^1,4,5, and Dafna Ben Bashat^1,2,5

¹Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel, ²Sagol Brain Institute, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel, ³School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel, ⁴Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁵Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

Synopsis

Keywords: Fetal, Infection

We aimed to examine whether MR spectroscopy (MRS) within the deep grey matter can detect brain metabolic changes in fetal cytomegalovirus infection. Retrospective data from 47 fetuses with brain sonography, MRI, and MRS scans were used: 27 women had a positive PCR on amniocentesis.

Seven (out of the 27) fetuses had brain MRI findings common to CMV. NAA+NAAG, and Cr were significantly lower in fetuses with PCR+ and MRI findings. No differences were detected in fetuses without imaging findings (PCR+ and PCR-). These metabolic changes could reflect brain impairments.

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