Abstract #1250

Site Effects in Multisite Fetal Brain MRI: a Morphological Study of Early Brain Development

Xinyi Xu¹, Haoan Xu¹, Tianshu Zheng¹, Yutian Wang¹, Chi Zhou¹, Jiaxin Xiao^1,2, Ruike Chen¹, Mingyang Li¹, Cong Sun³, Guangbin Wang⁴, Xianglei Kong⁵, Qingqing Zhu⁵, Jingshi Wang⁶, Hong Yu⁶, Yu Zou⁷, Guohui Yan⁷, and Dan Wu¹

¹Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²School of Biomedical Engineering & Imaging Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom, ³Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P.R. China., Beijing, China, ⁴Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁵Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China, ⁶Dalian Municipal Women and Children’s Medical Center (Group), Dalian, China, ⁷Department of Radiology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

Keywords: Fetal, Brain, Multisite; morphological development; harmonization; cortical thicknessStudies have shown that the non-biological site-related effects may induce bias in multisite neuroimaging studies among adults and adolescents. It is unknown how site effects would affect the analysis of fetal brain MRI and which acquisition factors are critical in quantitative analysis. In this study, we identified site effects, including manufacture, field strength, in-plane resolution, and slice-thickness on volume and cortical thickness measurements in normal fetuses. We also showed these site effects could be effectively removed with ComBat-GAM while preserving developmental pattern indicating that the harmonization procedure is necessary when combing multisite imaging data to study fetal brain morphological development.

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