Keywords: Quantitative Imaging, AtherosclerosisT1 mapping could provide more reliable quantitative measurements of plaques than traditional T1w MR images. In this study, the feasibility of in vivo quantitative T1 mapping of intracranial plaque had been demonstrated for the first time using a 3D SNAP with golden angle radial k-space sampling (GOAL-SNAP) sequence. Symptomatic patients showed significantly lower intraplaque T1 values than asymptomatic patients (1695.21 ± 493.23 vs. 2241.76 ± 300.28 ms, p=0.045). Quantifying plaque T1 values and enhancement through 3D GOAL-SNAP T1 mapping images is promising for characterizing the symptomatic plaques, serving as one potential tool for further plaque analysis.
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