Abstract #1255
Subject-specific detection of macro- and micro-structural alterations of deep gray matter nuclei using submillimeter 7T quantitative MRI
Gian Franco Piredda1,2,3, Alexandre Cabane4,5, Samuele Caneschi1,6,7, Tom Hilbert1,6,7, Gabriele Bonanno8,9,10, Thomas Troalen11, Jean-Philippe Ranjeva4,5, Ludovic de Rochefort4,5, David Seiffge12, Martina Goeldlin12, Robert Hoepner12, Roland Wiest9,13, Piotr Radojewski9,13, Tobias Kober1,6,7, Arnaud Le Troter4,5, and Bénédicte Maréchal1,6,7
1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 2Human Neuroscience Platform, Fondation Campus Biotech Geneva, Geneva, Switzerland, 3CIBM-AIT, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 5AP-HM, CHU Timone, Pôle d'Imagerie Médicale, CEMEREM, Marseille, France, 6Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 7LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 8Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Bern, Switzerland, 9Translational Imaging Center (TIC), Swiss institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, 10Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 11Siemens Healthcare SAS, Saint-Denis, France, 12Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland, 13Support Center for Advanced Neuroimaging, Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland
Synopsis
Keywords: Quantitative Imaging, Tissue Characterization, Ultra-high field MRIHigh-resolution 7T MRI allows to directly visualize deep gray matter nuclei (DGN), especially within the thalamus, and building reference ranges of volumes and relaxation times for these structures is of clinical relevance. Methods to automatically segment DGN at 7T have been recently proposed. In this study, we segmented DGN from a cohort of 132 healthy subjects scanned with the MP2RAGE at 7T to obtain both T1-weighted images and T1 maps. Reference ranges of volumes and T1 values were established and proved valuable in revealing both macro- and micro-structural tissue alterations in selected cases of patients with neurodegeneration.
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